• 09 MAY 16
    Cloprostenol isopropyl ester

    Cloprostenol isopropyl ester

    Application The intermediate of Cloprostenol.
    (+)-Cloprostenol is a synthetic analog of prostaglandin F2α (PGF2α). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. (+)-Cloprostenol is the optically active, 15(R) enantiomer of cloprostenol responsible for the majority of its biological activity. It is 200 times more potent than PGF2α in terminating pregnancy when given subcutaneously at a daily dose of 0.125 μg/kg in rats and hamsters, without the side effects associated with PGF2α.1 (+)-Cloprostenol was also shown to be a potent inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 value of 3 x 10-12 M.2 Cloprostenol isopropyl ester is a more lipid soluble form of cloprostenol.

    Synonyms ISOPROPYL CLOPROSTENATE; Isopropyl-(5Z)-7-{(1R,2R,3R,5S)-2-[(3R)-4-(3-chlorphenoxy)-3-hydroxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl}-5-heptenoat

    CAS Number 157283-66-4 | Molecular Formula C25H35ClO6 | Molecular Weight 466.99

    SMILES CC(C)OC(=O)CCC/C=CC[C@H]1[C@H](C[C@H]([C@@H]1C=C[C@H](COc2cccc(c2)Cl)O)O)O

    StdInChI InChI=1S/C25H35ClO6/c1-17(2)32-25(30)11-6-4-3-5-10-21-22(24(29)15-23(21)28)13-12-19(27)16-31-20-9-7-8-18(26)14-20/h3,5,7-9,12-14,17,19,21-24,27-29H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12?/t19-,21-,22-,23+,24-/m1/s1

    StdInChIKey OCNSAYQJDKJOLH-JSMWQALTSA-N

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