• 10 MAY 16
    Travoprost

    Travoprost

    Application Travoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure.

    Synonyms (+/-)-16-(M-TRIFLUOROMETHYLPHENOXY)TETRANORPROSTAGLANDIN F2; 15(S)-FLU-IPR; 15(S)-FLUPROSTENOL ISOPROPYL ESTER; (+)-FLUPROSTENOL ISOPROPYL ESTER; FLUPROSTENOL ISOPROPYL ESTER; FLU-IPR; 1-methylethyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoate; Travatan; Travatan Z

    CAS Number 157283-68-6 | Molecular Formula C26H35F3O6 | Molecular Weight 500.5477

    SMILES FC(F)(F)c2cc(OC[C@H](O)/C=C/[C@@H]1[C@H]([C@@H(O)C[C@H]1O)CC=C/CCCC(=O)OC(C)C)ccc2

    StdInChI InChI=1S/C26H35F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,19,21-24,30-32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21-,22-,23+,24-/m1/s1

    StdInChIKey MKPLKVHSHYCHOC-AHTXBMBWSA-N

    Similar Products Prostaglandin

    Available Impurities

    Epoxide Derivative

    Structure-of-1314-Epoxy-derivative-of-Travoprost1

    Impurity 1 Epoxide Derivative

    Chemical Name: (5Z)-(9S,11R,15S)-9,11,15-Trihydroxy-13,14-epoxy-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5-prostadienoic acid, isopropyl ester

    Appearance: Yellow oil

    Identification: HNMR,MS,HPLC

    Purity: 98%min(HPLC)

    15-epi Diastereomer

    Structure-of-15-epi-Diastereomer

    Impurity 2 15-epi Diastereomer

    Chemical Name: (5Z,13E)-(9S,11R,15S)-9,11,15-Trihydroxy-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5,13-prostadienoic acid, isopropyl ester

    Appearance: Yellow oil

    Identification: HNMR,MS,HPLC

    Purity: 98%min(HPLC)

    5,6-trans Isomer

    Structure-of-56-trans-Isomer

    Impurity 3 5,6-trans Isomer

    Chemical Name: (5E,13E)-(9S,11R,15R)-9,11,15-Trihydroxy-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5,13-prostadienoic acid, isopropyl ester

    Appearance: Yellow oil

    Identification: HNMR,MS,HPLC

    Purity: 98%min(HPLC)

    15-keto derivative

    Structure-of-15-keto-Travoprost-CAS-404830-45-1

    Impurity 4 15-keto derivative

    Full Name: (5Z,13E)-(9S,11R)-9,11-Dihydroxy-15-oxo-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5,13-prostadienoic acid, isopropyl ester

    Appearance: Yellow oil

    CAS: 404830-45-1

    Identification: HNMR,MS,HPLC

    Purity: 98%min(HPLC)

    • PRODUCT DETAILS

      Properties of Travoprost

      Appearance Light yellow to almost colorless oil
      Flash Point 307.5°C
      Boiling Point 584.8°C at 760 mmHg
      Density 1.245g/ml
      Refractive Index 1.547

       

      Description of Travoprost

      Standard USP
      Identification Method TLC, HPLC
      Assay 96.0%-102%
      Solubility Soluble in chloroform,ethyl acetate, acetone, practically insoluble in water
      Specific Rotation +52°~+58°,(C=1 CH2Cl2)
      Water 1.0% max
      Related Compounds Epoxide derivative ≤0.40%
      15-epi Diastereomer ≤0.1%
      5,6-trans Isomer ≤3.5%
      15-Keto derivative ≤0.3%
      Any other impurities ≤0.1%
      Total other impurity ≤1.0%
      Related Solvents Isopropanol ≤0.5%
      Ethyl acetate ≤0.25%
      n-Hexane ≤0.029%
      Ethanol ≤0.5%
      Storage Glass bottle, 2-8°C for shipment and 0 ℃ for long time storage
      Symbol exclamation-mark-jpgexclamation-mark-jpgGHS02, GHS07
      Risk Statements (Europe) 11-36/37/38
      Safety Statements (Europe) 16-26-36

      Travoprost-CAS-157283-68-6-NMR1

      Travoprost-CAS-157283-68-6-NMR1

      Travoprost-CAS-157283-68-6-NMR2

      Travoprost-CAS-157283-68-6-NMR2

      Travoprost-CAS-157283-68-6-NMR3

      Travoprost-CAS-157283-68-6-NMR3
      Travoprost CAS 157283-68-6 at Watson International Ltd(Sales Link) http://watson-int.com/travoprost-cas-157283-68-6-2/
      Travoprost CAS 157283-68-6 at Caming Pharmaceutical Ltd http://caming.com/travoprost-cas-157283-68-6/
      Travoprost CAS 157283-68-6 at Watson Noke Scientific Ltd http://watsonnoke.com/travoprost-cas-157283-68-6/